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Clinical studies on pyridoxine in relation to neurological effects (see Table 2 for particular person/anecdotal evidence) Duration Dosage Authors Subjects Number of Findings Conclusions (mg/day) therapy No changes in distal Patients with motor Duration too Del Tredici et al carpal tunnel 24 150 or 300 four months latency or brief to evaluate (1985) syndrome self-assesneurological effects sment questionnaire the situation may be as a result of pyridoxine defiEllis et al Patients with No opposed ciency; typical treatment (1979) (and carpal tunnel 35 one hundred-300 up to 12 neurologischedule of 12 weeks research cited); syndrome weeks cal effects (Ellis, 1987) is of too quick Ellis (1987) reported period to access neurological effects Patients with No assessDuration too Kerr (1977) premenstrual 70 40-one hundred 2 months ment of aspect brief to evaluate syndrome effects neurological effects No neurological comSmall group measurement however plications in very extended duration; Patients with 22 patients infiuence of the or nerve Mitwalli et al hyperoxaluria 22 250-500 1-6 years conduction disease on (1984) (kidney abnormapyridoxine handling, stones) necessities and lities in 7 sufferers neurological response aren’t identified studied intimately Small group measurement but very No abnorextended period; the malities of absence of results at Patients with motor or doses equivalent to 10-ninety Mpofu et al homocystei17 200-500 10-24 years sensory mg/kg/day means that (1991) nuria nerve these patients might show conduction lowered responsiveness velocities to the neuronal antagonistic effects of pyridoxine Pauling (1984) Undefined >5000 200 not given No details No particulars available; cites Hawkins sufferers cannot be assessed No assesResults from a survey Pullon et al Women 410 not described not described sments of of 1826 girls; no (1989) potential information on tolerability neuropathy and side effects No effects Small variety of topics and very limited Tolis et al Women 9 200 or 400 2 months on growth duration of remedy; (1977) hormone or no assessment of prolactin neurological effects No distinction in Women with unwanted side effects Duration too Williams et al premenstrual 204 (out 100 3 months between brief to access (1985) syndrome of 434) therapies neurological results and placebo groups Data assessment for A systematic review of printed and Women with stories of unpublished Wyatt et al premenstrual 526 (out 50-600 up to 4 unwanted side effects; randomised (1999) syndrome of 910) months 1 reported placebo controlled case of trials; all research of neurological inadequate duration unwanted effects 37 europa. 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